The Camarilla is an alliance of the six major Vampire Clans (Brujah, Toreador, Ventrue, Malkavian, Nosferatu, and Gangrel), all sworn to uphold the Masquerade and the other Traditions, enforcing the status quo in the days before Gehenna. During Gehenna, the Black Hand faction of the rival Sabbat defected to join them, and the awakening of most of the Antediluvians and the breaking of the Masquerade wide open drove several minor clans into joining the Camarilla for protection. The Ravnos, Giovanni, Assamite, Followers of Set (Settite), and Salubri clans all agreed to join the Camarilla, and following their defeat in the war, also mostly joined them in exile in the Wraithlands and later in the Kingdom of Enoch. Jointly led for many years by King Ventrue and Queen Arikel, the death of both remaining Antediluvians and the destruction of the Enoch System led to the near total breakup of the Camarilla. Between the official efforts of the Federation to wipe them out with Crusader Teams on the one hand, and the attacks of the Sabbat and their leader Mordred, the only surviving Antediluvian, on the other hand, the Camarilla seemed finished as an organization. Most Brujah and surviving members of the minor clans deserted to join the Sabbat.
However, with the re-emergence from hiding of Ennoia, the Antediluvian founder of Clan Gangrel, the Camarilla began to put itself together around her...and then she surprised nearly everyone by openly allying with Mordred. Putting his Sabbat and her Camarilla together, they could have ruled jointly over nearly all Vampires. But then Malkav returned from his self-imposed exile, and he became the focus of all those Vampires who refused to work with the Sabbat. Many Brujah and minor clans re-defected back to his Camarilla, seeing the Sabbat under Mordred and Ennoia as simply becoming an even worse bastion of entrenched hierarchical priveliege than even the old Camarilla had been.